GRP94 (HSP90B1) Rabbit Polyclonal Antibody

CAT#: AP07590PU-N

GRP94 (HSP90B1) rabbit polyclonal antibody, Aff - Purified



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CNY 6,116.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution ELISA: 1/5000 - 1/25000.
Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 1/500 - 1/2500.
Reactivity Chicken, Drosophila, Human, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide.
Specificity Amino acids 289-300 of human Hsp90 protein.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preserevative.
State: Aff - Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Immunoaffinity Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name heat shock protein 90kDa beta family member 1
Background Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.
Synonyms Tumor rejection antigen 1, GRP94
Reference Data
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway, Pathways in cancer, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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