ARHGEF11 (1-50) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 0.1 - 0.5 µg/ml.
Reactivity	Bovine, Canine, Chicken, Equine, Human, Monkey, Mouse, Rat, Chimpanzee
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a portion of the amino acids 1-50 of Human ARHGEF11
Specificity	This antibody recognizes Rho Guanine Exchange Factor (GEF) 11 (ARHGEF11) at aa 1-50.
Formulation	PBS containing 0.05% Sodium Azide as preservative and 0.2% Gelatin as stabilizer State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Rho guanine nucleotide exchange factor 11
Database Link	Entrez Gene 9826 Human UniProt ID O15085
Background	ARHGEF11 (Rho guanine nucleotide exchange factor 11) acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. It exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite outgrowth, and mediates activation of Rho in response to stimulation by activated Galpha12/13. Rat ARHGEF11 interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. ARHGEF11 is also thought to be involved in a pathway known to play a role in both insulin secretion and action.
Synonyms	KIAA0380, PDZ-RhoGEF, GTRAP48
Reference Data

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