Jagged1 (JAG1) (110-125) Rabbit Polyclonal Antibody

CAT#: AP08812PU-N

Jagged1 (JAG1) (110-125) rabbit polyclonal antibody, Aff - Purified



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CNY 5,511.00


货期*
5周

规格
    • 50 ug

Cited in 1 publication.

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution ELISA: 1/2500 - 1/10000.
Immunocytochemistry.
Immunofluorescence: 1/100 - 1/500.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/250 - 1/1000.
Reactivity Human, Chimpanzee, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to aa 110-125 of Human Jagged-1 protein.
Specificity Recognizes Human Jagged-1 (JAG1).
Formulation PBS, pH 7.2 containing 0.01% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Protein A Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name jagged 1
Background Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome.
Synonyms Jagged-1, hJ1, JAGL1
Note Predicted Molecular Weight: 134 kDa.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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