PCB (PC) (886-899) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/16000. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 0.03 - 0.1 µg/ml.
Reactivity	Bovine, Canine, Human, Mouse, Porcine, Rat, Bat, Equine, Hamster, Monkey, Rabbit
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an Internal region of Human PC
Specificity	Recognizes Pyruvate Carboxylase (PC) at aa 886-899.
Formulation	Tris saline buffer, pH 7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	pyruvate carboxylase
Database Link	Entrez Gene 5091 Human UniProt ID P11498
Background	Pyruvate Carboxylase (PC, PCB) requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. PCB is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Synonyms	Pyruvate carboxylase mitochondrial, PCB
Reference Data

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