NF2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Peptide ELISA: antibody detection limit dilution 1:32000. Immunohistochemistry: This product has been successfully used by customers on Formalin/PFA-fixed paraffin-embedded sections of Zebrafish Brain Cortex.
Reactivity	Zebrafish
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide from the internal region of the protein sequence according to NP_998116.1
Specificity	This antibody detects Neurofibromin 2 (Internal).
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Gene Name	neurofibromin 2 (merlin)
Database Link	Entrez Gene 4771 Human UniProt ID P35240
Background	Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
Synonyms	Neurofibromin-2, NF2, SCH, Schwannomin, Schwannomerlin
Reference Data
Protein Families	Druggable Genome

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