CSEN (KCNIP3) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blot: 1/1,000.  Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of Human KChIP3.
Specificity	This antibody detects KChIP3 at N-term.
Formulation	PBS with 0.09% (W/V) Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C fore month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	potassium voltage-gated channel interacting protein 3
Database Link	Entrez Gene 30818 Human UniProt ID Q9Y2W7
Background	KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.
Synonyms	KCNIP3, CSEN, DREAM, KCHIP3, DRE-antagonist modulator
Note	Calculated Molecular weight: 29231 Da
Reference Data

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