GABA A Receptor gamma 2 (GABRG2) (400-410) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: Limit Dilution: 1/16000. Western blot: 1-3 µg/ml. Approx 50kDa band observed in Mouse and Rat Brain lysates (calculated MW of 55.1kDa according to Mouse NP_032099.1 and 54.1kDa according to Rat NP_899156.1).
Reactivity	Bovine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_944494.1; NP_000807.2; NP_944493.2.
Specificity	This antibody is expected to recognize all reported isoforms: NP_944494.1; NP_000807.2; NP_944493.2.
Formulation	Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	gamma-aminobutyric acid type A receptor gamma2 subunit
Database Link	Entrez Gene 14406 MouseEntrez Gene 29709 RatEntrez Gene 2566 Human UniProt ID P18507
Background	GABA A receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA A. Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA A Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The binding of GABA to GABA A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system "overload" can resulting in blackouts, rapid body contractions, seizures and epilepsy.
Synonyms	GABRG-2, GABA A Receptor subunit gamma-2
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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