Activin Receptor Type IIA (ACVR2A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/500 - 1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 30-80 of Human ACTR-IIA.
Specificity	This antibody detects endogenous levels of ACTRIIA protein. (region surrounding His59)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 48 kDa
Gene Name	activin A receptor type 2A
Database Link	Entrez Gene 11480 MouseEntrez Gene 29263 RatEntrez Gene 92 Human UniProt ID P27037
Background	Members of the transforming growth factor beta superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (ACVR2A) or ACTRIIB (ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation and morphogenesis in a dose dependent manner.
Synonyms	ACTR-IIA, ACTRIIA, Activin A receptor type IIA
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

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