PSMA4 Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/4000 (Detection Limit). Western blot: 0.3-1 µg/ml. This antibody detects a band of ~28kDa in lysates of cell line K562, NIH3T3 and in lysates of Human Tonsil, Human Peripheral Blood Mononucleocytes and in Mouse and Rat Spleen.
Reactivity	Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_002780.1 and NP_001096138.1
Specificity	This antibody is expected to recognize both reported isoforms (NP_002780.1 and NP_001096138.1).
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	proteasome subunit alpha 4
Database Link	Entrez Gene 26441 MouseEntrez Gene 29671 RatEntrez Gene 5685 Human UniProt ID P25789
Background	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA4 is a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	Proteasome subunit alpha type-4, Macropain subunit C9, Proteasome component C9, HC9, PSC9, Proteasome subunit L
Note	Calculated Molecular Weight: 29.5kDa (NP_002780.1)
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Proteasome

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