Aromatase (CYP19A1) (475-486) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/128000. Immunohistochemistry on Paraffin Sections: 4 µg/ml. Western Blot: 0.1 - 0.3 µg/ml.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from internal region of human CYP19A1
Specificity	This antibody detects Aromatase at aa 475-486. It is expected to recognise both reported isoforms (NP_000094.2 and NP_112503.1), which are identical.
Formulation	Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 19 subfamily A member 1
Database Link	Entrez Gene 1588 Human UniProt ID P11511
Background	Aromatase, also known as estrogen synthetase, is a P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. Aromatase is present in many tissues including skin, muscle, brain, adipose, and placenta where it may contribute to sex-specific differences in cellular metabolism.
Synonyms	Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19
Reference Data
Protein Families	Druggable Genome, P450
Protein Pathways	Androgen and estrogen metabolism, Metabolic pathways

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