NPY1R (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: At 1μg/ml with the appropriate system to detect NPY1R in cells and tissues. Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect NPY1R in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide mapping at the C-terminal of human NPY1R
Specificity	This antibody detects Neuropeptide Y receptor 1 (C-term).
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	neuropeptide Y receptor Y1
Database Link	Entrez Gene 18166 MouseEntrez Gene 29358 RatEntrez Gene 4886 Human UniProt ID P25929
Background	Neuropeptide Y Receptor Y1 (NPY1R) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiological activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system.. Two major subtypes of NPY receptor (Y1 and Y2) have been defined by pharmacological criteria. NPY1R and NPY2R encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. NPY1R is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.
Synonyms	NPYR, NPYY1, Neuropeptide Y receptor 1
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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