AMD1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect SAMDC in cells and tissues. Immunohistochemistry on paraffin sections: At 0.5-1μg/ml to detect SAMDC in formalin fixed and paraffin embedded tissues. Immunohistochemistry on frozen sections: At 0.5-1μg/ml to detect SAMDC in formalin or acetone fixed tissues. Immunocytochemistry: At 2-3μg/ml to detect SAMDC in acetone fixed cell. Antigen retrieval by Pepsin and Trypsin is required.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence at the C-terminal of human SAMDC
Specificity	This antibody detects AMD1 (C-term). No cross reactivity with other proteins.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	adenosylmethionine decarboxylase 1
Database Link	Entrez Gene 11702 MouseEntrez Gene 81640 RatEntrez Gene 262 Human UniProt ID P17707
Background	S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC), is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.
Synonyms	AdoMetDC, SAMDC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arginine and proline metabolism, Cysteine and methionine metabolism, Metabolic pathways

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