GST3 (GSTP1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect GSTpi in cells and tissues. Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect GSTpi in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Immunocytochemistry: At 0.5-1μg/ml to detect GSTpi in acetone fixed cell. Antigen retrieval by Pepsin and Trypsin is required.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A peptide mapping at the C-terminus of GSTpi of human origin
Formulation	State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	1.2% sodium acetate or neutral PBS. If 0.5ml of PBS is used, the antibody concentration will be 100μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	glutathione S-transferase pi 1
Database Link	Entrez Gene 14870 MouseEntrez Gene 24426 RatEntrez Gene 2950 Human UniProt ID P09211
Background	Glutathione S-transferases pi, also known as GST3, present in all tissues and cells, with the exception of red cells, in which only erythrocyte GST (GSTe) is observed. The GST-pi gene has 7 exons and 6 introns contained within approximately 2.8 kilobases. The GST-pi gene is mapped to chromosome 11 .Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin. GSTP does not contribute in vivo to the formation of glutathione conjugates of acetaminophen but plays a novel and unexpected role in the toxicity of this compound.
Synonyms	Glutathione S-transferase P, GSTP1-1, GST pi, GST class-pi, FAEES3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Pathways in cancer, Prostate cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.