CEACAM1 (N-term) Rabbit Polyclonal Antibody

CAT#: AP26025PU-L

CEACAM1 (N-term) rabbit polyclonal antibody, Aff - Purified



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CNY 4,917.00


货期*
5周

规格
    • 200 ug

Product images

Specifications

Product Data
Applications ELISA, FC, WB
Recommend Dilution Western blot: 1-5 μg/ml.
ELISA: 1-5 µg/ml.
FACS: 2-20 μg/ml.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure recombinant Human soluble CEACAM-1 (N-term)
Specificity This antibody will detect recombinant Human soluble CEACAM-1. It shows cross-reactivity with several other CEACAM familiy members.
There is no cross-reactivity with Human CEACAM-8.
Formulation PBS pH 7.4
State: Aff - Purified
State: Lyophilized purified IgG fraction
Preservative: None
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Protein A Affinity Chromatography
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store at 2-8°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name carcinoembryonic antigen related cell adhesion molecule 1
Background Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1; also BGP) is a 160 kDa member of the CEACAM branch of the CEA gene family of the immunoglobulin superfamily (1-3). It is one of seven human CEACAM subfamily genes that are essentially divided equally between type I trans-membrane proteins (CEACAM1, 3-4) and GPI-linked molecules (CEACAM5-8). There is no CEACAM2 in human. The gene for human CEACAM1 codes for a 526 amino acid (aa) type I transmembrane protein that contains a 34 aa signal sequence, a 394 aa extracellular domain (ECD), a 24 aa transmembrane segment, and a 74aa cytoplasmic region (4, 5). The ECD contains one N-terminal V-type followed by three C2-type Ig-like domains. It shows considerable glycosylation (1). The cytoplasmic region shows one ITIM motif and a calmodulin binding site (1-3). There are three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. All ten alternate splice forms contain the V-type Ig-like domain (aa's 35-142). The three soluble forms also contain the first two C2-type Ig like domains (aa's 145 317), with differences coming in the third C2-type Ig- like domain (6). The seven transmembrane isoforms are highly divergent. Full-length mouse and rat CEACAM1 are approximately 57% aa identical to human CEACAM1; in the V-type Ig-like domain, they are 58% and 56% aa identical, respectively. The full-length molecule is found on neutrophils, bile duct epithelium, activated NK cells, colonic columnar epithelium and endothelium.
Synonyms BGP, BGP1, Biliary glycoprotein 1
Reference Data
Protein Families Druggable Genome, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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