Factor IX (F9) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, Neutralize
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Neut.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Human Factor IX purified from plasma.
Specificity	Specific for FIX as analyzed by Immunoelectrophoresis and ELISA.
Formulation	10 mM HEPES, pH 7.4, 0.15 M Sodium Chloride, 50% Glycerol State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	coagulation factor IX
Database Link	Entrez Gene 2158 Human UniProt ID P00740
Background	Coagulation Factor IX (F9) circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
Synonyms	Christmas factor, PTC
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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