CD11b (ITGAM) Chicken Polyclonal Antibody

CAT#: AP31807PU-N

CD11b (ITGAM) chicken polyclonal antibody, Aff - Purified



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CNY 7,688.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IF, IHC
Recommend Dilution Immunocytochemistry.
Immunohistochemistry.
Recommended Dilutions: 1/2000-1/5000.
Quality Control: This antibody was analyzed by Immunohistochemistry (at 3 µg/ml) using Fluorescein-labeled Goat anti-Chicken IgY (1/500 dilution, Cat.-No AP31795FC-N) or HRP-labeled Goat anti-Chicken IgY (1/2000 dilution, Cat.-No AP31795HR-N) as the secondary reagent.
Reactivity Human, Mouse
Host Chicken
Clonality Polyclonal
Immunogen Synthetic peptide KLH-conjugated corresponding to a sequence shared between the Mouse (NP_001076429.1) and Human gene products (NP_001139280.1).
After repeated injections, immune eggs were collected, and the IgY fractions were purified from the yolks.
Specificity Recognizes Integrin Alpha-M (MAC-1, OX-42 Antigen).
Formulation 10mM PBS, pH 7.2 containing 50% Glycerol and 0.02% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified (filter sterilized) IgY fraction.
Concentration lot specific
Purification Affinity Chromatography using a peptide column.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted in the dark at 2-8°C.
Gene Name integrin subunit alpha M
Background Integrin Alpha M (also known as MAC-1 and CD11b) is a 1142 amino acid protein (MAC-1): expressed in various antigen-presenting cells of the immune system, including microglial cells of the central nervous system. This is the same protein that is recognized by the Ox-42 Mouse monoclonal antibody.
CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
Synonyms ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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