FANCE Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	Peptide ELISA: 1/32000 (Detection limit).  Western blot: Preliminary experiments gave an approx 70kDa band in Human Adipose and Uterus lysates after 0.1 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 58.7kDa according to NP_068741.1. The 70kDa band was successfully blocked by incubation with the immunizing peptide.  Immunohistochemistry on Paraffin Sections: 3-6 μg/ml. In paraffin embedded Human Placenta shows nuclear staining in some trophoblasts.
Reactivity	Bovine, Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of Human FANCE (NP_068741.1).
Specificity	This antibody detects FANCE.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Fanconi anemia complementation group E
Database Link	Entrez Gene 2178 Human UniProt ID Q9HB96
Background	FANCE promotes the nuclear accumulation of FANCC. FANCE protein is part of the FA nuclear complex, binding FANCC & FANCD2. It is required for the nuclear accumulation of FANCC and provides a bridge between the FA complex and FANCD2. FANCC mutants do not bind FANCE or prevent chromosome breakage.
Synonyms	Fanconi anemia group E protein, FACE
Reference Data

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