CSEN (KCNIP3) (N-term) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/8000 (Detection limit).  Western blot: 1-3 μg/ml. In transfected HEK293 transiently expressing Human KCNIP3 a band of approx. 30kDa was observed. No bands are observed in the non-transfected HEK293.
Reactivity	Bovine, Canine, Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide with sequence from the N-terminus of Human KCNIP3 (NP_038462.1).
Specificity	This antibody is expected to recognize Isoform 1 of KCNIP3 (NP_038462.1) only.
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Purification: Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	29.2 kDa according to NP_038462.1.
Gene Name	potassium voltage-gated channel interacting protein 3
Database Link	Entrez Gene 30818 Human UniProt ID Q9Y2W7
Background	KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.
Synonyms	KCNIP3, CSEN, DREAM, KCHIP3, DRE-antagonist modulator
Reference Data

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