EMAP II (AIMP1) (137-149) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Peptide ELISA: 1/32000 (Detection limit).  Western blot: 0.1-0.3 μg/ml. Approx 37kDa band observed in Human Lymph Node and Uterus lysates (calculated MW of 37.0kDa according to NP_001135887.1).  Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. In paraffin embedded Human Pancreas shows staining in the cytoplasm towards the alpha cells periphery.
Reactivity	Human, Porcine, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_004748.2; NP_001135888.1.
Specificity	This antibody is expected to recognize both reported isoforms (NP_004748.2; NP_001135888.1). Reported variants represent identical protein: NP_004748.2, NP_001135887.1
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Database Link	Entrez Gene 9255 Human UniProt ID Q12904
Background	EMAPII is an approximate 20kDa apoptosis-induced pro-inflammatory cytokine, produced by enzymatic cleavage of a precursor identical to the p43 auxiliary component of the aminoacyl-tRNA synthetase complex. Studies have shown the ability of EMAPII to induce monocyte and neutrophil chemotaxis, stimulate tissue factor-dependent coaggulation, elevate the expression of E- and P-selectins and tumour necrosis factor receptor-1, induce stress-related apoptosis in endothelial cells, inhibit angiogenesis of vascular beds, and suppress primary and metastatic tumour growth.
Synonyms	EMAP-2, EMAP-II, AIMP1
Reference Data

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