TIMP3 (175-211) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	Flow Cytometry: 0.5-1 µg/106 cells.  Immunofluorescence: 1-2 µg/ml.  Western Blotting:  0.5-1 µg/ml.  Immunoprecipitation: 1-2 µg/500 µg protein lysate. Immunohistochemistry on Formalin-Fixed Paraffin Sections: 1/200-1/400 for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Positive Control: Placenta or breast carcinoma.
Reactivity	Bovine, Canine, Equine, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 175-211 of Human TIMP3
Specificity	This antibody recognizes TIMP-3 (Tissue Inhibitor of Metalloproteinase-3).
Formulation	10mM PBS State: Purified State: Liquid purified IgG fraction from Serum Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Predicted Protein Size	30 kDa
Gene Name	TIMP metallopeptidase inhibitor 3
Database Link	Entrez Gene 7078 Human UniProt ID P35625
Background	TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors.  TIMP’s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Synonyms	Protein MIG-5, TIMP-3
Reference Data

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