TAPA1 (CD81) Rat Monoclonal Antibody [Clone ID: QV-6A8-S3]

Specifications

Product Data
Clone Name	QV-6A8-S3
Applications	ELISA, FC, WB
Recommend Dilution	Flow Cytometry: 1.2 µg/106 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	cDNA encoding Human CD81
Specificity	Recognizes Human CD81.  Other species not tested. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD81 molecule
Database Link	Entrez Gene 975 Human UniProt ID P60033
Background	CD81 (TAPA-1) belongs to the transmembrane 4 superfamily (tetraspanin family). CD81 is a widely expressed cell-surface protein that is characterized by the presence of four transmembranic domains, short N and C termini, a small extracellular loop (SEL) and a large extra-cellular loop (LEL) (1). It is expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin and plays a role in the regulation of cell development, cell-growth and signal transduction. CD81 plays a critical role in Hepatitis C Infection and is involved in HCV entry due to its ability to interact with virus' E1/E2 glycoproteins (2,3). CD81 is an essential HCV host factor as silencing of CD81 expression by CD81-specific monoclonal antibodies in hepatoma cells inhibits HCV entry (4).
Synonyms	S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28
Reference Data

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