Uroplakin Ib (UPK1B) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	Western blot: 1:1,000. Immunohistochemistry on paraffin sections: 1:50~100. Flow cytometry: 1:10~50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 159~188 amino acids from the Central region of human UPK1B
Specificity	This antibody detects Uroplakin-1b (UPK1B) (Center).
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	uroplakin 1B
Database Link	Entrez Gene 7348 Human UniProt ID O75841
Background	UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Synonyms	UP1b, Uroplakin Ib, UPIb, Tetraspanin-20, TSPAN20, Tspan-20
Note	Molecular Weight: 29643 Da
Reference Data
Protein Families	Transmembrane

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