DOCK5 Rabbit Polyclonal Antibody

CAT#: AP54883SU-N

DOCK5 rabbit polyclonal antibody, Serum



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CNY 6,600.00


货期*
8周

规格
    • 200 ul

Cited in 1 publication.

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution

ELISA.
Western Blot: 1/200-1/2000. 
Immunohistochemistry: 1/50-1/500.

Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from C-terminal domain of Dock5 protein
Specificity This antibody reacts specifically with 23 and 215 kDa Mouse Dock5 proteins.  
Cross reacts with 215 kDa Human protein.
Formulation State: Serum
State: Lyophilized serum
Preservative: None
Reconstitution Method Restore in distilled Water
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name dedicator of cytokinesis 5
Background DOCK 5 (dedicator of cytokinesis protein 5) is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative splicing events.
Synonyms DKFZp451J181; DKFZp779M164; DKFZp781J211; FLJ21034
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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