Claudin-11 / CLDN11 Oligendodendrocyte Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/5000. Immunocytochemistry: 1/400. Immunohistochemistry: 1/50-1/500.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 15 residue synthetic peptide derived from C-terminal domain of 22 kDa Claudin-11
Specificity	Reacts with Rat 22 kDa OSP protein derived from CNS samples
Formulation	State: Serum State: Lyophilized serum Preservative: None
Reconstitution Method	Restore in 0.2 ml distilled water.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer Avoid repeated freezing and thawing.
Database Link	UniProt ID Q99P82
Background	Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
Synonyms	OSP, OTM
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.