Slc17a6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, EM, IHC, WB
Recommend Dilution	ELISA. Electron Microscopy: 1/200. Western Blot: 1/2000. Immunohistochemistry: 1/5000.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 19 residue synthetic peptide derived from C-terminal domain of Rat Vesicular Glutamate Transporter type 2 (MW: 55-60kD).
Specificity	This antibody reacts with 55-60 kD protein. It does not cross reacts with VGLUT1 and VGLUT3.
Formulation	0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified powder Preservative: None
Reconstitution Method	Restore in distilled water.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 17 member 6
Database Link	Entrez Gene 84487 Rat UniProt ID Q9JI12
Background	Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Subcellular Locaction: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Tissue Specificity: Expressed in brain. Expressed in hippocampal neurons (at protein level). Developement Stage: Expressed in brain throughout development. Transiently expressed in hippocampal neurons during the first week after birth, with expression decreasing thereafter. Miscellaneous: Mice lacking this protein exhibit an elevated rate of perinatal lethality. Surviving animals display a strong reduction in evoked glutamergic responses in thalamic neurons. Reduction of protein level in homozygous and heterozygous knockouts leads to a graded reduction in the amplitude of the postsynaptic response to single vesicle fusion in thalamic neurons, consistent with a role for this protein in determining quantal size.
Synonyms	Vesicular glutamate transporter 2, DNPI
Reference Data

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