ICAM1 Mouse Monoclonal Antibody [Clone ID: MEM-111]

Specifications

Product Data
Clone Name	MEM-111
Applications	ELISA, FC, IHC, WB
Recommend Dilution	Flow cytometry: Recommended dilution: 0.5-4 μg/ml. Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml; positive tissue: thymus, RE cells. Western blotting: Positive control: RAJI cell line K562 leukemia cell line, JY cell line, aa ctivated T-lymphocytes, non-reducing conditions.
Reactivity	Human, Rat, Bovine
Host	Mouse
Clonality	Monoclonal
Immunogen	Raji Human Burkitt's lymphoma cell line.
Specificity	Clone MEM-111 reacts with CD54.
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (95% pure by SDS-PAGE) Preservative: 15mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	intercellular adhesion molecule 1
Database Link	Entrez Gene 3383 Human UniProt ID P05362
Background	ICAM-1 (MW 90 kD) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
Synonyms	ICAM-1
Reference Data

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