HCV Core protein (70-90) Mouse Monoclonal Antibody [Clone ID: 11-B3]

Specifications

Product Data
Clone Name	11-B3
Applications	ELISA, IHC, WB
Recommend Dilution	Suitable for use in ELISA (~10-6), Western blot (1/1,000) and Immunohistochemistry (cryostat liver sections 1/20).
Reactivity	Hepatitis C Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant antigen HCV (genotype 1b).
Specificity	HCV Core Antigen (Amino Acids 70-90).
Formulation	1X PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction Preservative: 0.01% Sodium Azide
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Background	The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Synonyms	Hepatitis C Virus core protein
Reference Data

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