Neutrophil Elastase (ELANE) Mouse Monoclonal Antibody [Clone ID: 39A]

Specifications

Product Data
Clone Name	39A
Applications	ELISA, FC, FN
Recommend Dilution	ELISA. Flow Cytometry. Functional Assays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Elastase from Human Neutrophils.
Specificity	This antibody is specific for Neutrophil Elastase.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	elastase, neutrophil expressed
Database Link	Entrez Gene 1991 Human UniProt ID P08246
Background	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Elastase is a serine protease which exhibits endopeptidase activity on many proteins, its principal substrate, however, is elastin and it is unique among proteases in its ability to hydrolyse native elastin. It is present in the pancreas, leukocytes and serum. Elastase consists of a single polypeptide chain with a molecular weight of 29.5kDa. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Elastase 1 is not a pancreatic enzyme: clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.
Synonyms	ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE
Reference Data

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