Adenovirus (Hexon) Mouse Monoclonal Antibody [Clone ID: 2C4]

Specifications

Product Data
Clone Name	2C4
Applications	ELISA, IF, WB
Recommend Dilution	ELISA (1/20-1/200): Suitable as Capture antibody in a Sandwich ELISA with Product CatNo. BM908 as the Detection antibody. Immunofluorescence (1/10-1/50). Western blot (1/10-1/100).
Reactivity	Adeno-associated Virus
Host	Mouse
Clonality	Monoclonal
Immunogen	ATCC VR5 virus
Specificity	This Adenovirus antibody recognises the penton or hexon group antigen present in most ADV serotypes.
Formulation	PBS containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease. Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base.
Reference Data

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