Complement C3 (C3) (neoepitope) Chicken Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: The titer with native Human C3a was 1/5000.
Reactivity	Human
Host	Chicken
Clonality	Polyclonal
Immunogen	Peptide coupled to carrier protein. The antibody was generated against the carboxy-terminal neoepitope which is not exposed on C3, allowing discrimination between C3 and C3a.
Specificity	This antibody reacts with Human C3a and C3adesArg (67-76). It does not cross-react with C3 or C4a.
Formulation	PBS, pH 7.2 State: Aff - Purified State: Liquid purified IgY fraction Preservative: 0.09% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	complement component 3
Database Link	Entrez Gene 718 Human UniProt ID P01024
Background	The complement system is part of the innate immune system representing humoral defence. Activation of the complement cascade via the classical, the alternative or the Lectin pathway liberates several biologically active by-products, among them the anaphylatoxin C3a. Measurement of C3a (and C4a) in plasma or other body fluids can yield important clues about the pathological, and particularly also the inflammatory status of an organism. In serum, C3a activity is under strict control of the carboxypeptidase N. This enzyme rapidly cleaves the C-terminal arginine, thereby generating C3adesArg which shows greatly reduced biological activity as compared to C3a. Thus, the biological activity of C3a is focused mainly on its point of generation, while the degradation product C3adesArg remains relatively stable until it is cleared from the circulation.
Synonyms	CPAMD1, Complement component 3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Systemic lupus erythematosus

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