Neurotrophin 4 (NTF4) Mouse Monoclonal Antibody [Clone ID: OTI2E8]

Specifications

Product Data
Clone Name	OTI2E8
Applications	IF, IHC, WB
Recommend Dilution	WB 1:5000, IHC 1:50, IF 1:50
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 81-210 human NT4 (NP_006170) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22.2 kDa
Gene Name	neurotrophin 4
Database Link	NP_006170 Entrez Gene 25730 RatEntrez Gene 4909 Human UniProt ID P34130
Background	NT4 is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of NT4 is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NT4-deficient mice only show minor cellular deficits and develop normally to adulthood.
Synonyms	GLC1O; GLC10; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	MAPK signaling pathway, Neurotrophin signaling pathway

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