IRF3 Mouse Monoclonal Antibody [Clone ID: OTI5D2]

Specifications

Product Data
Clone Name	OTI5D2
Applications	IHC, WB
Recommend Dilution	WB 1:2000 IHC 1:50
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length protein expressed in 293T cell transfected with human IRF3 expression vector
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47.2 kDa
Gene Name	interferon regulatory factor 3
Database Link	NP_001562 Entrez Gene 718970 MonkeyEntrez Gene 3661 Human UniProt ID Q14653
Background	IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
Synonyms	interferon regulatory factor 3; MGC94729
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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