Langerin (CD207) Mouse Monoclonal Antibody [Clone ID: 310F7.02/HD26]

Specifications

Product Data
Clone Name	310F7.02/HD26
Applications	ELISA, FC, IHC
Recommend Dilution	Paraffin (Bouin) in human section, IHC,ELISA
Reactivity	Human, Mouse, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	mouse Langerin-transfected eukaryotic cells
Specificity	Mouse Langerin (intracellular epitope).
Formulation	Tris-NaCl pH 8 State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD207 molecule
Database Link	Entrez Gene 50489 Human UniProt ID Q9UJ71
Background	Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J. Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994)
Synonyms	CLEC4K, Dendritic Cell Marker
Reference Data

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