Prostate Specific Antigen (KLK3) Mouse Monoclonal Antibody [Clone ID: CHYH2]

Specifications

Product Data
Clone Name	CHYH2
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: Reacts with Human PSA.  Matched pair antibodies are DM1035 (Clone CHYH1) and DM1036 (Clone CHYH2). Western blot: 10 µg/ml MAb will allow visualization of 1 µg/lane of Human PSA. Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Sections using ABC immunoperoxidase assay.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Prostate Specific Antigen
Specificity	This antibody detects normal prostate, benign prostate hyperplasia and prostate malignant carcinoma.
Formulation	0.01M K2HPO4-KH2PO4, pH 7.0 State: Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Restore with double distillated water to a final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	kallikrein related peptidase 3
Database Link	Entrez Gene 354 Human UniProt ID P07288
Background	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.
Synonyms	Prostate-specific antigen, Semenogelase, Gamma-seminoprotein, P-30 antigen
Reference Data

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