CRISP3 Mouse Monoclonal Antibody [Clone ID: LV-2A2]

Specifications

Product Data
Clone Name	LV-2A2
Applications	ELISA, FC, WB
Recommend Dilution	Flow cytometry: 1.2 µg/10e6 cells. ELISA (detection): Clone LU-5E11-A7 as capture antibody. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunisation with cDNA encoding Human CRISP3.
Specificity	Recognizes Cysteine-Rich Secretory Protein 3 (CRISP3).
Formulation	Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cysteine rich secretory protein 3
Database Link	Entrez Gene 10321 Human UniProt ID P54108
Background	Cysteine-rich secretory protein 3 (CRISP3) belongs to the cysteine-rich secretory protein family. CRISPs are characterized by a cysteine-rich domain at the COOH terminal that form 8 intramolecular disulfide bonds (1). Mammalian members of the CRISP family are expressed predominantly in the male reproductive tract and are implicated in the process of reproduction from spermiogenesis, posttesticular sperm maturation and capacitation to oocyte-sperm fusion (2). CRISP3 is epithelium-specific and found predominantly in salivary gland, pancreas and prostate, and in less abundance in the epididymis, ovary, thymus and colon. CRISP3 is up-regulated in malignant prostatic epithelium, therefore, it can be used as a potential prostate cancer biomarker (3).
Synonyms	Cysteine-rich secretory protein 3, CRISP-3, SGP28
Reference Data
Protein Families	Secreted Protein

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