ErbB 3 (ERBB3) Mouse Monoclonal Antibody [Clone ID: DY-7G2]

Specifications

Product Data
Clone Name	DY-7G2
Applications	ELISA, FC, WB
Recommend Dilution	Flow cytometry: 1.2 µg/10e6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Genetic immunisation with cDNA encoding Human ErbB-3
Specificity	Recognizes Receptor Tyrosine-Protein Kinase ErbB-3.
Formulation	Phosphate buffered saline, pH 7.2 State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	erb-b2 receptor tyrosine kinase 3
Database Link	Entrez Gene 2065 Human UniProt ID P21860
Background	ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148-kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumours (2).
Synonyms	ERBB-3, c-erbB-3, HER-3
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane
Protein Pathways	Calcium signaling pathway, Endocytosis, ErbB signaling pathway

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