CCL3 Mouse Monoclonal Antibody [Clone ID: 125]

Specifications

Product Data
Clone Name	125
Applications	ELISA, WB
Recommend Dilution	ELISA, Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant human MIP-1α
Specificity	Reactive with recombinant MIP-1α. Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, GM-CSF, IL-7, IL-8, IL-16, IL-1β, bFGF, TGF-β, EGF, TNF-α and EPO.
Formulation	0.01M PBS, pH 7.2 State: Purified State: Lyophilized purified IgG
Reconstitution Method	Double distillated water is recommended to adjust the final concentration to 1.00 mg/ml
Purification	Protein G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (lyophilized and reconstituted) at -20°C. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine ligand 3
Database Link	Entrez Gene 6348 Human UniProt ID P10147
Background	Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.
Synonyms	CCL-3, MIP-1-alpha, C-C motif chemokine 3, MIP1A, Small-inducible cytokine A3, SCYA3, LD78 alpha, G0S19-1 protein
Reference Data

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