LYVE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC
Recommend Dilution	FACS analysis and Cell Sorting: Use at 2-5 µg/ml together with the appropriate secondary reagents. The unconjugated antibody can be used for ELISA experiments, Western blotting, FACS and Cell Sorting.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human soluble LYVE-1 (Ser24-Gly232) produced in insect cells.
Specificity	The antibody recognizes Human LYVE-1. Other species not tested.
Formulation	5mM PBS, pH 7.2 Label: Biotin State: Lyophilized purified IgG fraction Stabilizer: 50x BSA Preservative: 0.02% Sodium Azide
Reconstitution Method	Restore with sterile water to a concentration of 0.1-1.0 mg/ml
Purification	Antigen Affinity Chromatography
Conjugation	Biotin
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	lymphatic vessel endothelial hyaluronan receptor 1
Database Link	Entrez Gene 10894 Human UniProt ID Q9Y5Y7
Background	LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Synonyms	LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1
Reference Data

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