Myelin Basic Protein (MBP) (36-50) Rat Monoclonal Antibody [Clone ID: 14]

Specifications

Product Data
Clone Name	14
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry on frozen sections. ELISA.
Reactivity	Human, Mammalian
Host	Rat
Clonality	Monoclonal
Immunogen	Bovine myelin basic protein. Spleen cells from immunised outbred rats were fused with cells of the mouse NSO myeloma cell line.
Specificity	This antibody recognises myelin basic protein, recognising a synthetic peptide corresponding to amino acids 36-50, as strongly as intact human MBP. Clone 14 has also been reported to work in Western blotting.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant containing 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	myelin basic protein
Database Link	Entrez Gene 4155 Human UniProt ID P02686
Background	The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
Synonyms	MBP
Reference Data

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