CD18 (ITGB2) Mouse Monoclonal Antibody [Clone ID: MEM-48]

CAT#: SM3103R

CD18 (ITGB2) mouse monoclonal antibody, clone MEM-48, PE



Need it in bulk or conjugated?
Get a free quote

CNY 4,340.00


货期*
5周

规格
    • 100 Tests

Product images

Specifications

Product Data
Clone Name MEM-48
Applications FC, IHC, WB
Recommend Dilution Flow Cytometry analysis of human blood cells using 20 �l reagent / 100 �l of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Leukocytes of a patient suffering from a LGL-type leukemia
Specificity This antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin b2 subunit; b2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Label: PE
State: Liquid Ig fraction
Label: Conjugated with R-Phycoerythrin under optimum conditions
Purification Size-exclusion chromatography
Conjugation PE
Storage Condition Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name integrin subunit beta 2
Background CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Synonyms Integrin beta-2, MFI7
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...