alpha Synuclein (SNCA) (61-95) Mouse Monoclonal Antibody [Clone ID: 5C2]

Specifications

Product Data
Clone Name	5C2
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1/500-1/2,000). Immunohistochemistry on Paraffin Sections (10 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human Alpha-Synuclein (61-95) purified from E. coli.
Specificity	This antibody has the specificity against the NAC domain of Alpha-Synuclein (61-95).
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	Alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A beta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.
Synonyms	NACP, PARK1
Reference Data

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