SMC1 (SMC1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:1000-1:10000
Reactivity	Human, Mouse, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 248 of SMC1A (Uniprot ID#Q14683)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	143 kDa
Gene Name	structural maintenance of chromosomes 1A
Database Link	NP_006297 Entrez Gene 24061 MouseEntrez Gene 8243 Human UniProt ID Q14683
Background	Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq]
Synonyms	CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB
Note	Seq homology of immunogen across species: Mouse (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Oocyte meiosis

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