RASSF1 Rabbit Polyclonal Antibody

CAT#: TA308998

Rabbit polyclonal antibody to RASSF1 (Ras association (RalGDS/AF-6) domain family member 1)



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CNY 6,281.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Applications IF, WB
Recommend Dilution ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 50 and 344 of RASSF1 (Uniprot ID#Q9NS23)
Formulation 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 39 kDa
Gene Name Ras association domain family member 1
Background This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
Synonyms 123F2; NORE2A; RASSF1A; RDA32; REH3P21
Note Seq homology of immunogen across species: Mouse (91%), Rat (91%)
Reference Data
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Non-small cell lung cancer, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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