CACNA1H Mouse Monoclonal Antibody [Clone ID: S55-10]

Specifications

Product Data
Clone Name	S55-10
Applications	IHC
Recommend Dilution	WB, IP, ICC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2, accession number O95180
Formulation	PBS pH7.4, 50% glycerol
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel subunit alpha1 H
Database Link	NP_001005407 Entrez Gene 8912 Human UniProt ID O95180
Background	This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq]
Synonyms	CACNA1HB; Cav3.2; ECA6; EIG6; HALD4
Reference Data
Protein Families	Druggable Genome, Ion Channels: Calcium, Transmembrane
Protein Pathways	Calcium signaling pathway, MAPK signaling pathway

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