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Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody
CAT＃: TA321137S
Anti-ALPL Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 200-400 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 2-329amino acids of Human Alkaline phosphatase |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | alkaline phosphatase, liver/bone/kidney |
| Database Link | |
| Background | There are at least four distinct but related alkaline phosphatases: intestinal; placental; placental-like; and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2; while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is; therefore; referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however; mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia; a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary; however; depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. |
| Synonyms | AP-TNAP; APTNAP; HOPS; TNAP; TNSALP |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Folate biosynthesis, Metabolic pathways |
Documents
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