NOTCH4 Rabbit Polyclonal Antibody

CAT#: TA321659S

Anti-NOTCH4 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

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经常一起买 (2)
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Transient overexpression lysate of Notch homolog 4 (Drosophila) (NOTCH4)
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Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 25-50
Positive control: Human esophagus cancer
Predicted cell location: Cell membrane
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from C' 1989-2003 amino acids of Human notch 4
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name notch 4
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats; and an intracellular domain consisting of multiple; different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia; notch interaction with its cell-bound ligands (delta; serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human; but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network; and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands; and may play a role in vascular; renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
Synonyms INT3
Reference Data
Protein Families Druggable Genome
Protein Pathways Dorso-ventral axis formation, Notch signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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