ICOS Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 150-300 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 21-140 amino acids of human inducible T-cell co-stimulator
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	inducible T-cell costimulator
Database Link	NP_036224 Entrez Gene 29851 Human UniProt ID Q9Y6W8
Background	The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling; immune responses; and regulation of cell proliferation.?Enhances all basic T-cell responses to a foreign antigen; namely proliferation; secretion of lymphokines; up-regulation of molecules that mediate cell-cell interaction; and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2; but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Synonyms	AILIM; CD278; CVID1
Reference Data
Protein Families	Secreted Protein, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Primary immunodeficiency, T cell receptor signaling pathway

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