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PIWIL2 Rabbit Polyclonal Antibody
CAT＃: TA321862S
Anti-PIWIL2 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide peptide corresponding to a region derived from 107-120 amino acids of human piwi-like 2 (Drosophila) |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | piwi like RNA-mediated gene silencing 2 |
| Database Link | |
| Background | PIWIL2 belongs to the Argonaute family of proteins; which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization; which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes; germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB; SLC2A1; ITGA6; GJA7; THY1; CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed; acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors |
| Synonyms | CT80; HILI; mili; PIWIL1L |
| Reference Data | |
| Protein Pathways | Dorso-ventral axis formation |
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