DTX3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: SKOV3 cells IHC: 25-100 Positive control: Human tonsil Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 248 amino acids of human deltex homolog 3 (Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38 kDa
Gene Name	deltex 3, E3 ubiquitin ligase
Database Link	NP_848597 Entrez Gene 80904 MouseEntrez Gene 196403 Human UniProt ID Q8N9I9
Background	DTX3 functions as an E3 ubiquitin ligase. It is regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms	deltex3; RNF154
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Notch signaling pathway

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