BHLHA15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	BHLHA15 antibody was raised against a 18 amino acid peptide near the center of human BHLHA15.
Formulation	BHLHA15 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	BHLHA15 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 21 kDa; Observed: 24 kDa
Gene Name	basic helix-loop-helix family member a15
Database Link	NP_803238 Entrez Gene 17341 MouseEntrez Gene 25334 RatEntrez Gene 168620 Human UniProt ID Q7RTS1
Background	BHLHA15 (basic helix-loop-helix protein 15), also known as MIST1 (muscle intestine and stomach expression 1) belongs to the bHLH family of transcription factors and plays a role in regulating the transcriptional activity of MYOD1 in muscle cell development as well as serving as a key regulator of acinar cell function (1,2). BHLHA15 contains a basic helix-loop-helix (bHLH) domain and is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins. It may also negatively regulate bHLH-mediated transcription through a N-terminal repressor domain (3). It is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development (4).
Synonyms	BHLHB8; MIST1
Reference Data
Protein Pathways	Maturity onset diabetes of the young

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